2024 Sponge lncrna

Sponge lncrna

Author: ninp

August undefined, 2024

WebSponge RNAs modulate free sRNA levels in the cell through RNA-RNA interactions that sequester ("soak up") the sRNA and/or promote degradation of the target sRNA or the … Web23 Apr 2024 · Several lncRNA-related miRNA sponge interactions are experimentally confirmed. For the ground truth used in the validation, we have collected 581 …

Characterizing miRNA–lncRNA Interplay SpringerLink

Web1 Dec 2024 · MicroRNAs (miRNAs) are small non-coding RNAs with the length of ∼22 nucleotides. miRNAs are involved in many biological processes including cancers. Recent studies show that long non-coding RNAs (lncRNAs) are emerging as miRNA sponges, playing important roles in cancer physiology and development. Web16 Mar 2024 · In other words, lncRNA acts as a miRNA “sponge” which prevents miRNA from binding to its targets. The expression of many lncRNAs strongly relates to their neighboring genes, which means they can function as cis-regulators. lncRNA transcription may influence adjacent genes in mostly positive or negative manners . dr rothschild

Discovering lncRNA mediated sponge interactions in …

WebMechanistically, ASB16-AS1 served as a sponge for miR-760 and positively modulated the expression of its target HDGF. Finally, inhibiting miR-760 and restoring HDGF expression … Web“Molecular sponge” is that lncRNA competitively binds to microRNA based on base complementary pairing, thereby inhibiting the binding of microRNA to its target gene, thereby up-regulating the expression of the microRNA target gene and making it function. 36 In previous study, Zhou et al found that TRIM52-AS1 could sponge miR-514a-5p to ... Web8 Sep 2024 · lncRNA-PAGBC subnetwork in the GBC coexpression network. This subnetwork consists of 17 lncRNAs (red) and 30 protein-coding genes (green) with fold change ≥ 10.0 … colman dock to seatac

Characterizing miRNA–lncRNA Interplay SpringerLink

LncRNA SNHG7 sponges miR-216b to promote …

WebFor instance, lncRNA ATB targets the miR‐200b/Kindlin‐2 axis to facilitate the malignancy of ESCC. 18 LncRNA TUG1 enhances cisplatin resistance by regulating Nrf2 in ESCC. 19 LncRNA LINC00675 represses ESCC development and EMT via blocking Wnt/β‐catenin signaling. 20 FAM225A is a new lncRNA and has only been explored in nasopharyngeal … WebLncRNAs can act as miRNA sponges, reducing their regulatory effect on mRNAs. This function introduces an extra layer of complexity in the miRNA-target interaction network. … colman gallagher ucdWeb19 May 2016 · spongeScan is a web resource to find highly enriched MRE binding sites in lncRNAs. Users must provide the lncRNA transcript sequences in a FASTA file. These … dr rothschedl astrid

"Web4 Sep 2024 · Long non-coding RNAs (lncRNAs) can indirectly regulate mRNAs expression levels by sequestering microRNAs (miRNAs), and act as competing endogenous RNAs … " - Sponge lncrna

Sponge lncrna

LncRNA NEAT1 Sponges MiRNA-148a-3p to Suppress Choroidal

Web15 Dec 2024 · In this study, lncRNA DLEU2 was found to act as a miR-181a sponge and inhibited skeletal muscle regeneration and differentiation. The lncDLEU2-miR-181a-SEPP1 … Web21 Mar 2024 · Nrf2-lncRNA existed in the cytoplasm, suggestive of its function as a competing endogenous RNA [ceRNA, microRNA (miRNA) sponge]. Nrf2-lncRNA served as a ceRNA for polo-like kinase (Plk) 2 and cyclin-dependent kinase inhibitor 1 (p21 cip1) through binding of miRNA 128 and miRNA 224, inducing Plk2/Nrf2/p21 cip1 complexation for Nrf2 …

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Web15 Dec 2024 · In this study, lncRNA DLEU2 was found to act as a miR-181a sponge and inhibited skeletal muscle regeneration and differentiation. The lncDLEU2-miR-181a-SEPP1 pathway inhibits muscle differentiation and regeneration and can be used as a novel therapeutic target for the treatment of age-associated sarcopenia. WebNational Center for Biotechnology Information

WebTUG1 functions as a miR-9-5p sponge, and competes for binding of miR-9-5p, directly interfering with the interaction of miR-9-5p and eIF5A2, which blocked miR-9-5p-regulated Dox resistance in BC cells. Furthermore, miR-9-5p may degrade TUG1 after binding, but the regulation of TUG1 by miR-9-5p merits additional study. WebEmerging evidence demonstrates that circRNA functions as an miRNA sponge, thus regulating a series of physiological activities. We next predicted the target miRNAs of …

Web9 Apr 2024 · The lncRNA regulator of Akt signaling associated with HCC and RCC (LNCARSR; lnc-TALC) overexpression was shown to be accountable for temozolomide (TMZ) resistance and associated with glioblastoma recurrence. LNCARSR can sponge miR-20b-3p to enhance c-Met expression and improve chemoresistance to TMZ . WebLncRNA NEAT1 sponging miRNA-148a-3p targeting PTEN can modulate M2 macrophage polarization in mice CNV models as well as in bone marrow-derived macrophages …

Web15 Mar 2016 · The determinants of sponge lncRNA efficacy. Although lnc-7 was predicted to share 22 miRNAs with PTEN, it had no regulatory effect on PTEN expression. We further investigated the mechanism, whereby lnc-7 was unable to serve as an effective miRNA sponge. The miRNA-induced repression occurs dominantly in the cytoplasm and is …

WebMajority of RNAs expressed in animal cells lack protein-coding ability. Unlike other cellular RNAs, circular (circ)RNAs include a large family of noncoding (nc)RNAs that lack the 5' or … dr rothschild cabrillo cardiologyWebMicroRNAs (miRNAs) are small regulatory RNAs that act in an entangled web of interactions with target mRNAs to shape the cellular protein landscape by post-transcriptional control of mRNA decay and translation. miRNAs are themselves subject to numerous regulatory mechanisms that adjust their prevale … colman engineered air llcWebLncRNA NEAT1 Acts as miR-148b-3p Sponge to Regulate ROCK1 to Inhibit Cell Proliferation and Invasion. We co-transfected plasmids to verify the relationship of LncRNA NEAT1 … colman florist \u0026 greenhouse incWeb19 Feb 2024 · Following this, we hypothesized that certain lncRNAs may sponge miR-30e-5p and miR-30a-5p, leading to increased CHI3L1 production. To address this, a follow up in silico analysis was performed in order to predict possible interactions between miR-30a-5p/miR-30e-5p and lncRNAs. ... The lncRNA is found to be increased in serum of patients … colman jochemWeb11 May 2024 · Therefore, FGD5-AS1 should be a versatile and pleiotropic master regulator of gene expression as a sponge lncRNA for miRNAs. To validate the lncRNA–miRNA–mRNA regulatory relationship that we identified in heart tissues with TOF, we selected two miRNAs for each of the FGD5-AS1 targets: PTEN (hsa-miR-107 and hsa-miR-320-3p) and SMAD4 … col manish manraiWeb21 Aug 2024 · The “sponge” activity of lncRNAs can be scrutinized with the use of experimentally supported miRNA–mRNA pairs from TarBase and in silico characterized miRNA targets from microT-CDS . miRNA–lncRNA interactions can be enhanced with predicted pairs from LncBase v2 . dr rothrock prescottWeb1 Nov 2024 · RBPSponge identifies the occurrences of RBP-binding sites and CLIP peaks on lncRNAs, and enables users to run statistical analyses to investigate the regulatory … colman florist \\u0026 greenhouse inc