WebJul 17, 2024 · The distribution of TCR and pMHC encounter durations as a function of shear rate was calculated by combining dynamics of a microsphere in laminar flow with an estimate of the diffusion volumes of TCR and pMHC reactive sites (SI Appendix, Fig. S1). A molecular encounter was defined to begin and last while the diffusion volume of a TCR … WebJul 5, 2024 · We here present a disulfide-stabilized and peptide-receptive human leukocyte antigen (HLA)–A*02:01 molecule (DS-A*02:01) that can be produced as a functionally empty molecule and forms pMHCs in a simple one-step peptide loading procedure, allowing high-throughput pMHC generation.
Peptide-MHC Class I Tetramers Can Fail To Detect Relevant ... - PubMed
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