Nettet17. mar. 2024 · Intriguingly in experimental autoimmune encephalomyelitis (EAE), whereas ICAM-1 is up-regulated by EC and many other cell types, disease symptoms were reduced in ICAM-1 null mice (Icam1 tm1Alb) but were unexpectedly exacerbated in Icam1 tm1Bay, possibly due to T-cell dysfunction. 18, 21, 22 As with endotoxemia, Icam1 tm1Jcgr … Nettet23. sep. 2024 · Subsequently, we generated a phage-displayed single-chain variable fragment (scFv) library using splenocytes from ICAM1-immunized mice and selected a novel ICAM1-specific scFv, mG2-scFv. Using mG2-scFv as the extracellular antigen binding domain, we constructed ICAM1-specific CAR-T cells and demonstrated the …
ICAM-1/CD54 Antibody (15.2) SCBT - Santa Cruz Biotechnology
NettetDifferential basal expression of ICAM1 in mouse spleen, mouse lung, mouse kidney, and rat heart (positive for ICAM1) and cell line A549 (ICAM1 negative; Holden et al., 2004, … NettetGene target information for Icam1 - intercellular adhesion molecule 1 (house mouse). Find diseases associated with this biological target and compounds tested against it in … historical funny tee shirts
BV510 Hamster Anti-Mouse CD54 - BD Biosciences
NettetRecombinant Mouse ICAM1. Packaging. 1 kit. Application. For research use only. Not for use in diagnostic procedures. Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA) Biochem/physiol Actions. Intercellular adhesion molecule-1 (ICAM-1) is a member of immunoglobulin (Ig) superfamily. NettetHowever, EIU induction in WT mice resulted in a significant upregulation of Icam1 mRNA in the retina and the RPE. Importantly, MMP-3 deficiency clearly attenuated the gene expression levels of Icam-1 , since a reduction of 76% of Icam1 was observed in both the retina ( p ≤ 0.05) and RPE ( p ≤ 0.0001) of MMP-3 −/− mice as compared to WT mice. NettetICAM-1 (intercellular adhesion molecule-1), also known as CD54, is a transmembrane protein that is upregulated on endothelial and epithelial cells at sites of inflammation. It mediates the vascular adhesion and paracellular migration of leukocytes expressing activated LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). It also binds several non … historical gaming consultant