WebThe highly conserved nature of the ATP-binding pocket and the anticipated or experienced side effects of its inhibition gave rise to a new class of PLK1 targeting compounds that target the PLK1 tandem polo-box ... Gimenez-Abian JF, Gerlich D, et al. Roles of polo-like kinase 1 in the assembly of functional mitotic spindles. Curr Biol. 2004 ... Web17 jun. 2016 · The mitotic spindle assembly checkpoint ... the 24 h post‐taxol treatment time point from four independent experiments is quantified in the graph on the right side and normalized to control shRNA (± SD). ... Small‐molecule inhibitors mimicking this effect, that is, SMAC mimetics, ...
List of Mitotic inhibitors - Drugs.com
Web6 feb. 2014 · We are characterizing the rate-limiting phosphatases at consecutive levels of the mitotic exit: (1) the establishment of stable spindle-chromosome interactions, (2) the silencing of the spindle checkpoint, (3) the inhibition of mitotic cell death, (4) the initiation of chromosome segregation, and (5) the preparation for interphase by bulk … Webthe epidermis. To study how aPKC controls mitotic spindle orientation, we developed a minimal keratinocyte culture system in which planar spindle positioning occurs in the absence of intercellular adhesive polarity cues. As in vivo, either loss of aPKC or knockdown of the LGN orthologue AGS-3 increased spindle angle, which was dependent on LGN. diversity and inclusion evaluation phrases
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WebSupporting: 4, Mentioning: 35 - Kinesin spindle protein (KSP), an ATPase responsible for spindle pole separation during mitosis that is present only in proliferating cells, has … Web1 okt. 2010 · In fact, various drugs that target microtubules and thus interfere with the function of the mitotic spindle are in clinical use for the treatment of various human … WebCommon adverse effects of chemotherapy Chemotherapeutic agents damage actively dividing cells, but can also affect tissues with a low mitotic potential (e.g., neurons ). Gastrointestinal tract Chemotherapy-induced nausea and vomiting Chemotherapy-induced diarrhea Mucositis soft tissue erythema mucosa dysphagia Constipation Intestinal … diversity and inclusion executive order