WebJan 19, 2024 · We found that CKD mice and Klotho hypomorphic mice in particular present high FGF23 serum levels. In the latter case, the very high systemic levels of FGF23 that accompany the defect in Klotho expression might be the primary responsible factor for the cardiac alterations related to the prolonged ventricular repolarization observed in CKD. WebAug 27, 2015 · Klotho-hypomorphic mice ( kl/kl) suffer from severe vascular calcification and rapid aging. The calcification is at least in part caused by excessive 1,25 (OH) 2 D 3, Ca 2+, and phosphate concentrations in blood, which trigger osteogenic signaling including upregulation of alkaline phosphatase ( Alpl ).
A Fragment of Klotho Improves Cognition and Synaptic Plasticity …
WebAug 9, 2024 · In this open access paper, researchers report on use of a portion of the … WebOct 24, 2024 · Klotho-hypomorphic (kl/kl) mice are known to show phenotypes of … microspheres technologies and global markets
Therapeutic Interference With Vascular Calcification—Lessons …
WebHypomorphic mutant Klotho mice also exhibited a phenotype of accelerated aging, which was restored by p16 ablation . Since Klotho is an important factor in aging, Klotho gene-modified mice have been widely used in research on aging. However, Klotho gene-modified mice may be inappropriate for research on renal aging owing to the systemic aging ... WebInterestingly, serum levels of soluble Klotho decline with age in mice and men [19, 20]. This is in line with reports on klotho hypomorphic mice (ΔKlotho), a well-established model of premature aging [21]. Those mice are genetically characterized by an insertional mu-tation in the promoter of the klotho gene leading to a se- WebMay 4, 2024 · Analysis of klotho-hypomorphic mice and mice with vitamin D3 overload uncovered several pathophysiological mechanisms participating in the orchestration of vascular calcification and several... newshosting cyber monday