WebApr 30, 1994 · Medical Herbalism 04-30-94 6 (1): 10. The question of hepatotoxicity of pyrrolizidine alkaloids (PA) in herbal medicines has come to be a matter of clamorous … WebUnsaturated pyrrolizidine alkaloids are hepatotoxic, that is, damaging to the liver. [8] [9] PAs also cause hepatic veno-occlusive disease and liver cancer. [10] PAs are …

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Web摘要： Clivorine is a representative naturally occurring hepatotoxic otonecine-type pyrrolizidine alkaloid. Our previous study has demonstrated that clivorine induces liver damage via metabolic activation to form the reactive pyrrolic ester followed by covalent binding to liver tissue constituents. WebOnly those PAs with un-saturated necine base and an allylic ester group are hepatotoxic, as exemplified by retrorsine, lasiocarpine, incidine, monocratoline, etc., ( Xia et al., 2015 ), and these were summarized as hepatotoxic pyrrolizidine alkaloids (HPAs). fishing umbrellas with sides

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http://www.itmonline.org/arts/pas.htm WebIt is concluded that toxicokinetics play an important role in the overall toxicity of pyrrolizidine alkaloids and that kinetics should therefore be considered when defining REP values for combined risk assessment. Expand 2 PDF Save Alert Metabolism-mediated cytotoxicity and genotoxicity of pyrrolizidine alkaloids WebA. Romero is an academic researcher. The author has contributed to research in topic(s): Membrane permeability. The author has an hindex of 1, co-authored 2 publication(s) receiving 21 citation(s). fishing umbrella with side panels