2024 Griffithsin patent

Griffithsin patent

Author: mpdv

August undefined, 2024

WebNov 16, 2024 · Detailed Description: Q-Griffithsin (Q-GRFT) nasal spray is an investigational product that has broad spectrum antiviral activity. Q-GRFT is derived from … WebThe invention relates to an anti-viral Griffithsin polypep tide related conjugates, compositions, nucleic acids, vectors, host cells, antibodies, and methods for their production and SC. BACKGROUND OF THE INVENTION

Researchers just made a startling discovery about this nasal spray …

Webgriffithsin viral virus polypeptide hiv Prior art date 2004-06-01 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal … WebThis technology describes the lectin, Griffithsin (GRFT), isolated from red algae. GRFT shows significant broad-spectrum anti-viral activity making it a promising agent for use as … inc function in python

Compound derived from red algae may protect against Nipah virus

WebDec 1, 2006 · US Patent for Anti-viral griffithsin compounds, compositions and methods of use Patent (Patent # 8,088,729 issued January 3, 2012) - Justia Patents Search Anti-viral griffithsin compounds, compositions and methods of use Dec 1, 2006 - The United States of America as represented by the Secretary, Department of Health and Human Services WebThe results show that griffithsin is potently active (sub-nanomolar EC 50 values) against a broad range of HIV isolates including T-tropic viruses (utilizing CCR5 as a co-receptor) and M-tropic viruses (utilizing CXCR4 as a co-receptor). This picomolar level of activity is more potent than that described for most of the current anti-HIV agents utilized in therapy or in … WebFeb 10, 2016 · The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, … includability uk

An Anti-Viral Polypeptide: Griffithsin Technology Transfer

Griffithsin: An Antiviral Lectin with Outstanding

WebGriffithsin is moving into clinical trials as an anti-HIV microbicide. Based on the structure of griffithsin and the necessities of pharmaceutical product development and regulatory … WebJul 14, 2024 · A “Swiss army knife” protein that is active against several viruses may also offer some protection against Nipah virus, a lethal pathogen with no cure or vaccine. The “tool” is griffithsin, a compound extracted from the red algae Griffithsia. A modified version of the protein substantially increased survival rates when administered as a preventative … inc fxWebgriffithsin cov sars protein infection Prior art date 2024-08-24 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Pending Application number CN202410867243.0A Other languages English (en) Inventor ... includa training

"WebFeb 7, 2011 · US Patent for Griffithsin, glycosylation-resistant griffithsin, and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of use Patent (Patent # 8,394,764 issued March 12, 2013) - Justia Patents Search " - Griffithsin patent

Griffithsin patent

Frontiers Technoeconomic Modeling of Plant-Based Griffithsin ...

WebPatent Application No. 63/026,375 described above, as well as a second U.S. Provisional Patent Application No. 63/070,375 entitled “Q-Griffithsin Nasal Spray,” (HHS Ref. No. E-029-2024-1-US-01), filed on August 26, 2024. The Government of the United States is not a co-owner on this second US Provisional Patent Application, and it is therefore, WebAug 2, 2011 · Many natural product-derived lectins such as the red algal lectin griffithsin (GRFT) have potent in vitro activity against viruses that display dense clusters of …

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WebJan 23, 2015 · The lectin griffithsin (GRFT) is a potent antiviral agent capable of prevention and treatment of infections caused by a number of enveloped viruses and is currently … WebThe crystal structure of griffithsin, an antiviral lectin from the red alga Griffithsia sp., was solved and refined at 1.3 A resolution for the free protein and 0.94 A for a complex with mannose. Griffithsin molecules form a domain-swapped dimer, in which two beta strands of one molecule complete a …

WebJul 24, 2024 · Griffithsin is a marine algal lectin that exhibits broad-spectrum antiviral activity by binding oligomannose glycans on viral envelope glycoproteins, including those found in HIV-1, HSV-2, SARS, HCV and other enveloped viruses. Webparticular molecule carries no net electrical charge) of the modified griffithsin polypeptides can optimize the bioavailability of the modified griffithsin polypeptides in different compartments of the body (e.g., nasal cavity, lung, gut, small intestine, colon, blood, vagina, and rectum). The pH of wild-type griffithsin of SEQ ID NO: 2 is 5.1.

WebOct 6, 2024 · Virus entry into a susceptible host cell is the first step in the formation of all viral diseases. Controlling viral infections by disrupting viral entry is advantageous for … WebA safe and effective topical microbicide against HIV is urgently needed to prevent sexual transmission. Hence, we evaluated griffithsin (GRFT), a 12.7 kDa carbohydrate-binding …

WebGriffithsin, a Highly Potent Broad-Spectrum Antiviral Lectin from Red ...

WebOct 24, 2016 · Abstract. Griffithsin (GRFT), an algae-derived lectin, is one of the most potent viral entry inhibitors discovered to date. It is currently being developed as a … includablesWebJan 6, 2024 · This is a phase 1 study for intranasal application of Q-Griffithsin (Q-GRFT) spray as a prophylactic for severe acute respiratory syndrome-CoV-2. This randomized, placebo-controlled, single site will assess the local and systemic safety of intranasal Q-GRFT after 14 doses in approximately 45 adult participants. includable and excludable income wioaWebU.S. Patent Application 20240087359 for Griffithsin Mutants Griffithsin Mutants O'Keefe; Barry R. ; et al. [The United States of America,as represented by the Secretary,Department of Health and Human Services] inc galleryWebJul 25, 2024 · Griffithsin, or "GRFT", is an investigational product that is being developed as a microbicide. GRFT is a naturally occurring protein originally isolated from the red alga Griffithsia found in the South Pacific Ocean. GRFT is one of the most powerful, broad-spectrum antivirals ever tested and its activity is under study for potential ... include $ build_java_libraryWebparticular molecule carries no net electrical charge) of the modified griffithsin polypeptides can optimize the bioavailability of the modified griffithsin polypeptides in different … inc g-410WebApr 28, 2006 · 2GTY, 2GUC, 2GUD, 2GUE, 2GUX. PubMed Abstract: The crystal structure of griffithsin, an antiviral lectin from the red alga Griffithsia sp., was solved and refined at 1.3 A resolution for the free protein and 0.94 A for a complex with mannose. Griffithsin molecules form a domain-swapped dimer, in which two beta strands of one molecule … include $ build_prebuiltWebNov 4, 2024 · Griffithsin (GRFT) is a high-mannose oligosaccharide-binding lectin currently being evaluated in phase I clinical trials as a topical microbicide for the prevention of human immunodeficiency virus (HIV-1) … include -include