Chk1 molecular weight
WebCHEK1 protects vertebrate cells against spontaneous chromosome missegregation and is required to sustain anaphase delay when spindle function is disrupted by taxol (PMID:17276342). It has 3 isoforms … WebDetects a band of approximately 45 kDa (predicted molecular weight: 48 kDa). Flow Cyt Use 1µg for 10 6 cells. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. Target. Function. Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex).
Chk1 molecular weight
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WebWestern blot analysis of Chk1 using HeLa (lane 2) and NIH/3T3 (lane 3) cell extracts probed with Mouse anti Chk1 (MCA6041). Molecular weight marker is shown in lane 1. [close] Create mode – the default mode when you create a requisition and PunchOut to Bio-Rad. You can create and edit multiple shopping carts . Edit mode ... WebLow-molecular-weight cyclin E (LMW-E) is an N-terminus deleted (40 amino acid) form of cyclin E detected in breast cancer, but not in normal cells or tissues. ... Targeting the ATR-CHK1-RAD51 pathway with ATR inhibitor (ceralasertib), CHK1 inhibitor (rabusertib), or RAD51 inhibitor (B02) significantly decreased the viability of LMW-E ...
WebDec 1, 2024 · Checkpoint kinase 1 (Chk1) is a kinase instrumental for orchestrating DNA replication, DNA damage checkpoints, the spindle assembly checkpoint, and cytokinesis. ... Numbers indicate molecular weight markers (in kDa). B, co-IP between endogenous Chk1 and OGT. Chk1 immunoprecipitates were blotted with anti-Chk1 and anti-OGT antibodies. WebCHEK1 protects vertebrate cells against spontaneous chromosome missegregation and is required to sustain anaphase delay when spindle function is disrupted by taxol (PMID:17276342). It has 3 isoforms produced by alternative splicing with the molecular mass of 54 kDa, 44 kDa and 50 kDa. Protocols Standard Protocols
WebJun 30, 2024 · The induction of the DNA damage markers p-CHK1, p-CHK2, γH2AX, and p53 in whole embryos by maternal diabetes was suppressed by p21 deletion ... molecular weight 400. Pregnant WT diabetic and nondiabetic mice received intraperitoneal injections of rapamycin at a dose of 0.1 ml/g of body weight (2 mg/kg of body weight). ... WebThe Mucin family consists of Mucins 1-4, Mucin 5 (AC and B), Mucins 6-8, Mucins 11-13 and Mucins 15-17. The Mucin 16 protein (also commonly referred to as CA125), encoded for by the gene MUC16, is a very high molecular weight tumor antigen consisting of three domains: a carboxy terminal domain, an extracellular domain and an amino terminal …
WebFeb 12, 2016 · Our results showed an increase on Chk1 mRNA and protein levels in both MKN45 and AGS cells when compared to normal tissue. Two different isoforms of Chk1 …
WebMay 6, 2024 · CHK1 encodes a serine/threonine-protein kinase which is ... with similar birth rate or body weight (till 12 weeks) compared to those of ... Center for Excellence in Molecular Cell Science, Chinese ... cpcif dataWebAs stated above, the Chk family is mainly composed of Chk1 and Chk2. Structure and function of Chk1: The human Chk1 gene was found on chromosome 11q24. There are currently 7 known transcriptional variants with a molecular weight of 54 kD and 13 exons. The full-length cDNA is 1891 bp, consisting of 476 amino acids. cpci certificationWebOct 20, 2016 · Serine/threonine-protein kinase Chk1 Molecular Weight 54433.115 Da. References. Yang CY, Liu CR, Chang IY, OuYang CN, Hsieh CH, Huang YL, Wang CI, Jan FW, Wang WL, Tsai TL, Liu H, Tseng CP, Chang YS, Wu CC, Chang KP: Cotargeting CHK1 and PI3K Synergistically Suppresses Tumor Growth of Oral Cavity Squamous Cell … cp cigWebReliable separation and transfer of high molecular weight (HMW) proteins is a common challenge for life science researchers. Choosing the right gel is a key factor in the successful transfer of HMW proteins. A popular general-use gel is a 4–20% Tris-glycine gel, which can effectively separate a mixed range of proteins. cpci backplane schematicWebThe identification of SYK as a molecular target in B-lineage leukemia/lymphoma cells prompted the development of SYK inhibitors as a new class of anti-cancer drug candidates. ... by dephosphorylating checkpoint kinases, CHK1 and CHK2 are known to phosphorylate p34cdc2/CDK1 on threonine 14 (T14) and tyrosine 15 (Y15) and thereby CDC25C on its ... cpci insuranceWebChk1 antibody for FC, IF, IHC, WB,ELISA and reacts with human, mouse, rat. ... (PMID:19276361). It has 3 isoforms produced by alternative splicing with the molecular weight of 54 kDa, 44 kDa and 50 kDa. Protocols. Product Specific Protocols; WB protocol for Chk1 antibody 10362-1-AP: Download protocol: IHC protocol for Chk1 antibody … cpci connectorWebProtein target information for Serine/threonine-protein kinase Chk1 (human). Find diseases associated with this biological target and compounds tested against it in … cpci girders